Joshua H, Sharon Z, Gutglas E, Rosenfeld J, Ben-Bassat M
Am J Clin Pathol. 1977 Mar;67(3):289-95. doi: 10.1093/ajcp/67.3.289.
Renal biopsy specimens were obtained from nine patients with proteinuria and persistent macroscopic or microscopic hematuria. Histologic examination either disclosed no abnormality or showed moderate mesangial thickening and occasionally, evidence of focal segmental glomerulonephritis. Immunofluorescent studies revealed diffuse generalized mesangial deposits of IgA, IgG and betalc in all specimens. Fibrinogen deposits were present in the mesangial space in four specimens only, while IgM was uniformly absent. Serial sections of identical glomeruli allowed the localization of betalc within both IgA and IgG deposits. Ultrastructural studies of the renal biopsy specimens showed accumulation of electron-dense material in the subendothelial region of the capillary loops and the mesangium, with thickening of its matrix. Follow-up data indicated a generally good prognosis.
从9例蛋白尿伴持续性肉眼血尿或镜下血尿患者获取肾活检标本。组织学检查要么未发现异常，要么显示中度系膜增厚，偶尔有局灶节段性肾小球肾炎的证据。免疫荧光研究显示，所有标本中均有IgA、IgG和β1c在系膜区弥漫性沉积。仅4例标本的系膜区有纤维蛋白原沉积，而IgM均未检出。对相同肾小球的连续切片进行观察，发现β1c定位于IgA和IgG沉积物内。肾活检标本的超微结构研究显示，毛细血管袢内皮下区域和系膜区有电子致密物质积聚，其基质增厚。随访数据表明预后总体良好。
