Kelleher J, Humphrey C S, Homer D, Davison A M, Giles G R, Losowsky M S
Clin Sci (Lond). 1983 Dec;65(6):619-26. doi: 10.1042/cs0650619.
Serum vitamin A, retinol binding protein, prealbumin and transferrin have been studied in chronic renal failure patients receiving maintenance haemodialysis and after renal transplantation. Vitamin A and retinol binding protein were uniformly raised in haemodialysis patients and this was unrelated to the period on dialysis. There was a molar excess of retinol binding protein to both vitamin A and prealbumin as compared with normal individuals. Renal transplantation significantly reduces serum vitamin A and retinol binding protein concentrations but has no effect on prealbumin concentrations. The reduction in vitamin A and retinol binding protein is variable in individual patients and cannot be predicted either by the allograft function or time since transplantation. Several years after transplantation, with normal serum creatinine, both serum vitamin A and retinol binding protein levels may still be greatly increased. Despite the very high vitamin A and retinol binding protein concentrations, the close correlation between the two seen in normal individuals is well maintained. The continuing high vitamin A and retinol binding protein levels in patients with satisfactorily functioning transplants is unexplained.
对接受维持性血液透析的慢性肾衰竭患者以及肾移植后的患者的血清维生素A、视黄醇结合蛋白、前白蛋白和转铁蛋白进行了研究。血液透析患者的维生素A和视黄醇结合蛋白均一致升高，且这与透析时间无关。与正常个体相比，视黄醇结合蛋白在摩尔数上相对于维生素A和前白蛋白均过量。肾移植显著降低血清维生素A和视黄醇结合蛋白浓度，但对前白蛋白浓度无影响。维生素A和视黄醇结合蛋白的降低在个体患者中存在差异，且无法通过移植肾的功能或移植后的时间来预测。移植数年且血清肌酐正常后，血清维生素A和视黄醇结合蛋白水平可能仍会大幅升高。尽管维生素A和视黄醇结合蛋白浓度非常高，但正常个体中二者之间的密切相关性仍得到很好维持。移植肾功能良好的患者中维生素A和视黄醇结合蛋白水平持续居高的原因尚不清楚。
