Faugeron-Fonty G, Mangin M, Huyard A, Bernardi G
Gene. 1983 Sep;24(1):61-71. doi: 10.1016/0378-1119(83)90131-2.
We have investigated the structure and organization of the mitochondrial genomes of two related orir (ori-rearranged) spontaneous petite mutants of Saccharomyces cerevisiae. In these mutant genomes every repeat unit contains an inverted terminal duplication harboring a second (inverted) ori sequence, and tandem pairs of repeat units alternate with tandem pairs in inverted orientation. We have shown that orir genomes are organized as the genomes with inverted repeat units of ethidium bromide (EtBr)-induced petites, and we have clarified the mechanism by which such mutant mitochondrial genomes arise.
我们研究了酿酒酵母两个相关的ori（ori重排）自发小菌落突变体的线粒体基因组的结构和组织。在这些突变基因组中，每个重复单元都包含一个反向末端重复序列，该序列含有第二个（反向的）ori序列，并且重复单元的串联对与反向排列的串联对交替出现。我们已经表明，orir基因组的组织方式与溴化乙锭（EtBr）诱导的小菌落的具有反向重复单元的基因组相同，并且我们已经阐明了这种突变线粒体基因组产生的机制。
