通过全身给药脑啡肽减轻大鼠失忆症
Attenuation of amnesia in rats by systemically administered enkephalins.
作者信息
Rigter H
出版信息
Science. 1978 Apr 7;200(4337):83-5. doi: 10.1126/science.635578.
PMID:635578
Abstract
The pentapeptides methionine-enkephalin and leucine-enkephalin are both able to reduce experimentally induced amnesia in rats. In contrast to the possible analgesic activity of these peptides, the anti-amnesic effect is seen after systemic administration of dosages of 30 micrograms or lower. The nature of the anti-amnesic effect is different for the two peptides.
摘要
五肽甲硫氨酸脑啡肽和亮氨酸脑啡肽都能够减轻实验诱导的大鼠失忆。与这些肽可能的镇痛活性相反，在全身给予30微克或更低剂量后可观察到抗失忆作用。两种肽的抗失忆作用性质不同。
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