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Strain-dependent effects of naloxone on discrimination learning in mice.

作者信息

Castellano C

出版信息

Psychopharmacology (Berl). 1981;73(2):152-6. doi: 10.1007/BF00429207.

DOI:10.1007/BF00429207
PMID:6785806
Abstract

The effects of post-trial naloxone administration were studied in two inbred strains of mice. C57BL/6 (C57) and DBA/2 (DBA), tested in two different experimental conditions. These were a Y-water maze (requiring escape from water) and the Yerkes--Thompson--Bovet-Nitti apparatus for pattern discrimination (requiring escape from electric shock). Two series of experiments were carried out. In the first series, naloxone improved acquisition in DBA and impaired acquisition in C57 mice either trained to swim towards tha dark or to discriminate between oblique bars. Light-oriented behavior, perhaps due to non-conditioned tendencies, was improved in the Y-water maze following naloxone administration on both strains.

摘要

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本文引用的文献

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Brain Res. 1980 Sep 29;198(1):249-52. doi: 10.1016/0006-8993(80)90364-9.
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Psychopharmacology (Berl). 1980;67(3):235-9. doi: 10.1007/BF00431262.
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Memory facilitation by naloxone is due to release of dopaminergic and beta-adrenergic systems from tonic inhibition.
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Psychopharmacology (Berl). 1988;94(3):379-85. doi: 10.1007/BF00174693.
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Opioids and behavior: genetic aspects.阿片类药物与行为：遗传学方面
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Genetic control of hippocampal cholinergic and dynorphinergic mechanisms regulating novelty-induced exploratory behavior in house mice.
Experientia. 1989 Sep 15;45(9):839-45. doi: 10.1007/BF01954058.
纳洛酮对记忆的促进作用是由于多巴胺能和β-肾上腺素能系统从紧张性抑制中释放出来。
Psychopharmacology (Berl). 1980;67(3):265-8. doi: 10.1007/BF00431268.
4
Genotype-dependent sensitivity to morphine: role of different opiate receptor populations.基因型对吗啡的敏感性：不同阿片受体群体的作用
Brain Res. 1980 May 5;189(1):289-94. doi: 10.1016/0006-8993(80)90031-1.
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Facilitation of simultaneous visual discrimination by nicotine in four "inbred" strains of mice.
Psychopharmacologia. 1969;14(3):193-9. doi: 10.1007/BF00404217.
6
Lysergic acid diethylamide, amphetamine and chlorpromazine on water maze discrimination in mice.麦角酸二乙酰胺、苯丙胺和氯丙嗪对小鼠水迷宫辨别能力的影响。
Psychopharmacologia. 1971;19(1):16-25. doi: 10.1007/BF00403698.
7
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Psychopharmacologia. 1974;39(1):13-22. doi: 10.1007/BF00421454.
8
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9
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Psychopharmacology (Berl). 1976 Jul 9;48(1):37-43. doi: 10.1007/BF00423304.