Mitrou P S
Onkologie. 1983 Aug;6(4):192-4. doi: 10.1159/000215232.
21 patients with relapsing or primarily chemotherapy resistant acute myeloid or lymphocytic leukemia were treated with Aclacinomycin A (ACM). 25 mg/m2 ACM were given i.v. daily for 7 consecutive days. 17 out of 21 patients are evaluable, 2 with acute lymphocytic and 15 with acute myeloid leukemia. Two of the patients with acute myeloid leukemia entered complete remission. A further patient, primarily resistant to adriamycin and daunorubicin, experienced a partial remission. None of the patients with ALL responded to ACM.
21例复发或对化疗原发性耐药的急性髓性或淋巴细胞白血病患者接受了阿克拉霉素A(ACM)治疗。静脉注射给予阿克拉霉素A 25mg/m²,每日1次,连续7天。21例患者中有17例可进行评估,其中2例为急性淋巴细胞白血病,15例为急性髓性白血病。2例急性髓性白血病患者进入完全缓解期。另有1例对阿霉素和柔红霉素原发性耐药的患者出现部分缓解。所有急性淋巴细胞白血病患者对阿克拉霉素A均无反应。