Gallavan R H, Fondacaro J D, Jacobson E D
Proc Soc Exp Biol Med. 1983 Oct;174(1):74-8. doi: 10.3181/00379727-174-41706.
In this study, we examined the effects of both pharmacologically and mechanically induced increases in intestinal blood flow on intestinal oxygen consumption. Intraarterial infusions of prostacyclin (1-20 ng X kg-1 X min-1) significantly increased both blood flow and oxygen consumption under free flow conditions. However, the increase in oxygen consumption appears to be due to the corresponding increase in blood flow rather than a direct effect of prostacyclin on intestinal metabolism. This conclusion is supported by the finding that a mechanically induced increase in intestinal blood flow (60%) can also produce an increase in intestinal oxygen consumption (24%). These findings support the hypothesis that intestinal oxygen consumption is flow-dependent over a wide range of blood flows.
在本研究中，我们检测了药理学和机械诱导的肠血流量增加对肠氧消耗的影响。在自由流动条件下，动脉内输注前列环素（1 - 20 ng·kg⁻¹·min⁻¹）显著增加了血流量和氧消耗。然而，氧消耗的增加似乎是由于血流量的相应增加，而非前列环素对肠代谢的直接作用。机械诱导肠血流量增加60%也能使肠氧消耗增加24%这一发现支持了该结论。这些发现支持了这样一种假说，即在广泛的血流量范围内，肠氧消耗取决于血流量。
