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疟原虫在所罗门群岛的胎盘传播

The transplacental passage of malaria parasites in the Solomon Islands.

作者信息

Marshall D E

出版信息

Trans R Soc Trop Med Hyg. 1983;77(4):470-3. doi: 10.1016/0035-9203(83)90116-5.

DOI:10.1016/0035-9203(83)90116-5
PMID:6356502
Abstract

A prospective study was undertaken to determine the extent of transplacental passage of malaria parasites in affected women attending for delivery at Kilu'ufi Hospital, Malaita Province, Solomon Islands. 11 women had parasitaemia and in 10 of these the placenta was infected. Transplacental passage occurred in five. Parasites were identified in one infant. The low parasitaemia in cord blood suggests that passage is accidental and probably occurs in labour. Where parasite transfer occurred there was no evidence of clinical illness in the newborn child. There were three stillborn infants and three infants of low birth weight. This small study confirms that the placenta provides an effective barrier during malaria in pregnancy.

摘要

在所罗门群岛马莱塔省基卢乌菲医院,针对前来分娩的感染疟疾妇女,开展了一项前瞻性研究,以确定疟原虫经胎盘传播的程度。11名妇女患有寄生虫血症,其中10名妇女的胎盘受到感染。5例发生了经胎盘传播。在1名婴儿体内发现了寄生虫。脐带血中寄生虫血症水平较低,这表明传播是偶然发生的,可能发生在分娩过程中。发生寄生虫传播的情况下,没有证据表明新生儿患有临床疾病。有3例死产婴儿和3例低出生体重婴儿。这项小型研究证实,胎盘在孕期疟疾期间提供了有效的屏障。

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引用本文的文献

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Transplacental Transmission of Plasmodium falciparum in a Highly Malaria Endemic Area of Burkina Faso.
布基纳法索高度疟疾流行地区的恶性疟原虫经胎盘传播。
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Antibody-dependent transplacental transfer of malaria blood-stage antigen using a human ex vivo placental perfusion model.利用人体胎盘体外灌流模型进行依赖抗体的疟疾血期抗原经胎盘转移。
PLoS One. 2009 Nov 24;4(11):e7986. doi: 10.1371/journal.pone.0007986.
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Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence?撒哈拉以南非洲地区的先天性恶性疟原虫疟疾:罕见还是常见?
Parasitol Res. 2007 Sep;101(4):835-42. doi: 10.1007/s00436-007-0577-9. Epub 2007 Jun 5.