Schultz A, Jørgensen P M, Jørgensen S P
Acta Chir Scand. 1983;149(5):517-20.
A prospective, controlled trial of antibiotic therapy was carried out in 90 patients with perforated appendicitis. One randomly selected group received systemic metronidazole, started peroperatively, plus locally instilled ampicillin. The other group, also randomly selected, received only local ampicillin. There was no statistically significant difference in the overall frequency of postoperative septic complications (wound infection or intra-abdominal abscess) between the two groups, but wound infections were significantly fewer in the patients given metronidazole. There was no intergroup difference in hospitalization time. Treatment with systemic metronidazole and local ampicillin is recommended in patients operated on for perforated appendicitis.
对90例穿孔性阑尾炎患者进行了抗生素治疗的前瞻性对照试验。随机选择一组患者在手术时开始接受全身甲硝唑治疗，并局部注入氨苄青霉素。另一组同样随机选择，仅接受局部氨苄青霉素治疗。两组术后脓毒症并发症（伤口感染或腹腔内脓肿）的总体发生率无统计学显著差异，但接受甲硝唑治疗的患者伤口感染明显较少。两组的住院时间无差异。对于接受穿孔性阑尾炎手术的患者，建议采用全身甲硝唑和局部氨苄青霉素治疗。
