Bjerke J R, Matre R, Nilsen R
Acta Pathol Microbiol Immunol Scand C. 1983 Aug;91(4):233-6.
Epithelioid cells, giant cells and mononuclear cells in cryostat sections of lesional skin from 5 patients with chronic cutaneous sarcoidosis were characterized using an indirect immunofluorescence test with monoclonal antibodies. OKM1 (monocyte) antibody stained both epithelioid cells and giant cells as well as some cells in the periphery of the granulomas. OKM1 which reacts with most monocytes in peripheral blood, did not react with tissue macrophages in sections of normal skin, liver, spleen and kidney. The results indicate that the epithelioid and giant cells in the sarcoid granulomas are derived from blood monocytes. OKT3 (pan T cell) antibody stained the majority of cells surrounding the epithelioid cell islands. Examination of adjacent sections showed that more OKT4+ (helper/inducer) than OKT8+ (suppressor/cytotoxic) cells were present in the sarcoid lesions examined.
使用单克隆抗体间接免疫荧光试验对5例慢性皮肤结节病患者病变皮肤冰冻切片中的上皮样细胞、巨细胞和单核细胞进行了表征。OKM1（单核细胞）抗体对上皮样细胞、巨细胞以及肉芽肿周边的一些细胞进行了染色。OKM1与外周血中的大多数单核细胞发生反应，但在正常皮肤、肝脏、脾脏和肾脏切片中不与组织巨噬细胞发生反应。结果表明，结节病肉芽肿中的上皮样细胞和巨细胞来源于血液单核细胞。OKT3（全T细胞）抗体对上皮样细胞岛周围的大多数细胞进行了染色。对相邻切片的检查显示，在所检查的结节病病变中，OKT4 +（辅助/诱导）细胞比OKT8 +（抑制/细胞毒性）细胞更多。
