Pedersen F K, Henrichsen J, Schiffman G
Acta Pathol Microbiol Immunol Scand C. 1983 Aug;91(4):251-5.
Antibodies against pneumococcal capsular polysaccharide types 1, 3, 6A, 7F, 8 and 9N were determined before and 4 weeks after pneumococcal vaccination by both enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA) in 49 children, 42 of whom had been splenectomized. Using linear regression analysis a significant correlation between total antibody concentrations determined by ELISA and RIA was found for all 6 antigens (p less than 0.001 for each). The degree of correlation varied between types, antibodies against type 3 showing the best concordance, those against type 6A the poorest. In 84% of the samples assayed both the RIA and the ELISA determined antibody concentrations were either above (55%) or below (29%) the hypothetical protective antibody concentration.
采用酶联免疫吸附测定法（ELISA）和放射免疫测定法（RIA），对49名儿童在肺炎球菌疫苗接种前及接种后4周时针对1、3、6A、7F、8和9N型肺炎球菌荚膜多糖的抗体进行了测定，其中42名儿童已行脾切除术。通过线性回归分析发现，对于所有6种抗原，ELISA和RIA测定的总抗体浓度之间均存在显著相关性（每种抗原的p值均小于0.001）。不同类型之间的相关性程度有所不同，针对3型的抗体一致性最佳，针对6A型的抗体一致性最差。在84%的检测样本中，RIA和ELISA测定的抗体浓度要么高于（55%）要么低于（29%）假设的保护性抗体浓度。
