Sjöström L, Schutz Y, Gudinchet F, Hegnell L, Pittet P G, Jéquier E
Am J Physiol. 1983 Nov;245(5 Pt 1):E431-42. doi: 10.1152/ajpendo.1983.245.5.E431.
A test for determination of epinephrine sensitivity has been worked out using six healthy young women. Variables considered were metabolic rate, heart rate, respiratory frequency, blood pressure, blood glucose, plasma insulin, glycerol, free fatty acids, and lactate. After established basal conditions, epinephrine was infused at rates of 0.01, 0.03, and 0.1 microgram X kg fat-free mass-1 X min-1. Most variables responded to epinephrine in a dose-dependent manner. Physiological threshold plasma concentrations of epinephrine ranged from 95 to 250 pg/ml for different variables. Calculated maximal responses ranged from approximately -15% to +900% of basal values and infusion rates giving half-maximal responses from approximately 15 to 190 ng X kg fat-free mass-1 X min-1. On an average, metabolic rate increased by 8, 16, and 29%, respectively, at the three infusion rates, and the maximal metabolic response was calculated to be approximately 35%. The error in determining epinephrine-induced increments in metabolic rate was 7% of the response. As calculated from nonprotein RQ, carbohydrate oxidation increased and lipid oxidation decreased rapidly during the first 10 min of epinephrine infusion. Later, fat oxidation became more important. Results on epinephrine plasma metabolic clearance rate agreed with earlier results in the literature.
已设计出一种使用六名健康年轻女性来测定肾上腺素敏感性的试验。所考虑的变量有代谢率、心率、呼吸频率、血压、血糖、血浆胰岛素、甘油、游离脂肪酸和乳酸。在确立基础条件后，以0.01、0.03和0.1微克×每千克去脂体重-1×每分钟-1的速率输注肾上腺素。大多数变量对肾上腺素呈剂量依赖性反应。不同变量的肾上腺素生理阈值血浆浓度范围为95至250皮克/毫升。计算出的最大反应范围为基础值的约-15%至+900%，产生半数最大反应的输注速率范围为约15至190纳克×每千克去脂体重-1×每分钟-1。平均而言，在这三种输注速率下，代谢率分别增加了8%、16%和29%，计算出的最大代谢反应约为35%。测定肾上腺素诱导的代谢率增加的误差为反应的7%。根据非蛋白呼吸商计算，在输注肾上腺素的最初10分钟内，碳水化合物氧化迅速增加，脂质氧化迅速减少。后来，脂肪氧化变得更为重要。肾上腺素血浆代谢清除率的结果与文献中早期的结果一致。
