Boren C H, Roon A J, Moore W S
Surgery. 1978 Apr;83(4):382-91.
An experimental study, designed to investigate the feasibility of maintaining fresh, viable arterial allografts by cryopreservation, is presented. Cryopreserved femoral arterial allografts were shown to be equal in patency rate when compared with fresh controls. The cryopreserved allografts were shown to be superior to fresh allografts in the parameters of intimal integrity, absence of host rejection, and reduced surface thrombogenicity. This experimental study supports the thesis that cryopreservation in liquid nitrogen, utilizing 15% dimethyl sulfoxide (DMSO) and methylprednisolone as a cryoprotectant solution, is an excellent method of preserving and storing fresh allograft arteries for use as a small vessel replacement.
本文介绍了一项旨在研究通过冷冻保存来维持新鲜、有活力的动脉同种异体移植物可行性的实验研究。与新鲜对照组相比，冷冻保存的股动脉同种异体移植物在通畅率方面表现相当。在内膜完整性、无宿主排斥反应以及降低表面血栓形成性等参数方面，冷冻保存的同种异体移植物优于新鲜同种异体移植物。这项实验研究支持了这样一个论点，即使用15%二甲基亚砜（DMSO）和甲基强的松龙作为冷冻保护剂溶液，在液氮中进行冷冻保存，是保存和储存新鲜同种异体移植动脉以用作小血管替代物的一种极佳方法。
