双氯芬酸钠治疗输尿管绞痛：与安慰剂的双盲对照试验。

Diclofenac sodium in ureteral colic: a double-blind comparison trial with placebo.

作者信息

Vignoni A, Fierro A, Moreschini G, Cau M, Agostino A, Daniele E, Foti G, Grossi E

出版信息

J Int Med Res. 1983;11(5):303-7. doi: 10.1177/030006058301100510.

Abstract

A randomized prospective double blind study of the analgesic effect of 75 mg intramuscular diclofenac sodium (Voltaren), a potent prostaglandin synthetase inhibitor, versus placebo (saline solution) was carried out in 131 consecutive patients with acute ureteral colic. Diclofenac provided complete relief of pain 25 minutes after the injection in 59% of the cases, while placebo provided relief in 29% (p less than 0.01). Forty patients in the placebo group and seventeen patients in the diclofenac group needed an open injection of 75 mg diclofenac intramuscularly after 25 minutes due to persistent pain. Fifty-four of the fifty-seven patients treated with an open injection of diclofenac achieved complete relief of pain after 30 minutes. There were no side-effects of the treatment.

摘要

对131例连续性急性输尿管绞痛患者进行了一项随机前瞻性双盲研究，比较强效前列腺素合成酶抑制剂75毫克肌肉注射双氯芬酸钠（扶他林）与安慰剂（生理盐水）的镇痛效果。双氯芬酸钠注射后25分钟，59%的病例疼痛完全缓解，而安慰剂组为29%（p<0.01）。安慰剂组40例患者和双氯芬酸钠组17例患者因持续疼痛在25分钟后需要肌肉注射75毫克双氯芬酸钠。57例接受双氯芬酸钠开放注射治疗的患者中有54例在30分钟后疼痛完全缓解。治疗无副作用。