Hamilton I, Worsley B W, O'Connor H J, Axon A T
Gut. 1983 Dec;24(12):1148-51. doi: 10.1136/gut.24.12.1148.
Forty patients with duodenal ulcer were randomly allocated to treatment with either tripotassium dicitrato bismuthate tablets or cimetidine for six weeks. Endoscopically confirmed healing of the ulcer occurred in 80% treated with tripotassium dicitrato bismuthate tablets and in 85% treated with cimetidine. Symptomatic improvement was also similar in the two groups. Treatment with cimetidine was associated with an increase in pH of gastric aspirate during treatment and increased numbers of bacteria were isolated from the gastric aspirate during treatment, while the pH and bacterial flora of gastric aspirate did not change during tripotassium dicitrato bismuthate treatment. Serum and urinary bismuth levels rose during treatment with tripotassium dicitrato bismuthate and urinary excretion remained raised two weeks after cessation of treatment. Tripotassium dicitrato bismuthate tablets appear to be as effective as cimetidine in the treatment of duodenal ulcer without the potentially undesirable effects of a reduction in gastric acid secretion.
40例十二指肠溃疡患者被随机分为两组，分别服用枸橼酸铋钾片或西咪替丁，疗程6周。经内镜检查证实，服用枸橼酸铋钾片的患者溃疡愈合率为80%，服用西咪替丁的患者溃疡愈合率为85%。两组患者的症状改善情况相似。服用西咪替丁治疗期间，胃抽吸物的pH值升高，治疗期间从胃抽吸物中分离出的细菌数量增加，而服用枸橼酸铋钾治疗期间，胃抽吸物的pH值和细菌菌群未发生变化。服用枸橼酸铋钾治疗期间，血清和尿铋水平升高，停药两周后尿铋排泄仍维持在较高水平。枸橼酸铋钾片在治疗十二指肠溃疡方面似乎与西咪替丁同样有效，且不会产生胃酸分泌减少等潜在不良影响。
