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抗受体抗体可模拟胰岛素的作用，下调培养的人淋巴母细胞样（IM-9）细胞中的胰岛素受体。

Anti-receptor antibodies mimic the effect of insulin to down-regulate insulin receptors in cultured human lymphoblastoid (IM-9) cells.

作者信息

Taylor S I, Marcus-Samuels B

出版信息

J Clin Endocrinol Metab. 1984 Jan;58(1):182-6. doi: 10.1210/jcem-58-1-182.

DOI:10.1210/jcem-58-1-182
PMID:6358243
Abstract

Autoantibodies directed against the insulin receptor mimicked the effect of insulin to down-regulate insulin receptors in IM-9 cells. This down-regulation occurred at 37 C, but not at 15 or 22 C. As with insulin itself, antireceptor antibodies caused down-regulation by accelerating the rate of receptor degradation. Down-regulation induced by antireceptor antibody may play a role in desensitizing target cells to the effects of insulin.

摘要

针对胰岛素受体的自身抗体模拟了胰岛素下调IM-9细胞中胰岛素受体的作用。这种下调作用在37℃时发生，但在15℃或22℃时不发生。与胰岛素本身一样，抗受体抗体通过加速受体降解速率导致下调。抗受体抗体诱导的下调可能在使靶细胞对胰岛素作用脱敏中发挥作用。

相似文献

1
Anti-receptor antibodies mimic the effect of insulin to down-regulate insulin receptors in cultured human lymphoblastoid (IM-9) cells.抗受体抗体可模拟胰岛素的作用，下调培养的人淋巴母细胞样（IM-9）细胞中的胰岛素受体。
J Clin Endocrinol Metab. 1984 Jan;58(1):182-6. doi: 10.1210/jcem-58-1-182.
2
Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes.胰岛素受体自身抗体。对IM-9淋巴细胞中胰岛素-受体相互作用的影响。
J Clin Invest. 1977 Oct;60(4):784-94. doi: 10.1172/JCI108832.
3
Effect of Anti-Insulin Receptor Antibody on Insulin Dissociation from IM-9 lymphocytes.抗胰岛素受体抗体对胰岛素从IM-9淋巴细胞解离的影响。
Horm Metab Res. 1981 Sep;13(9):480-3. doi: 10.1055/s-2007-1019311.
4
The insulin receptor: characterization and regulation using insulin-antiinsulin antibody complexes as a probe for flow cytometry.胰岛素受体：利用胰岛素-抗胰岛素抗体复合物作为流式细胞术探针的表征与调控
J Clin Endocrinol Metab. 1985 May;60(5):1004-11. doi: 10.1210/jcem-60-5-1004.
5
Effect of down-regulation of insulin receptors on receptor-antibody binding.胰岛素受体下调对受体-抗体结合的影响。
Endocrinology. 1981 Feb;108(2):478-83. doi: 10.1210/endo-108-2-478.
6
Insulin receptor degradation is accelerated in cultured lymphocytes from patients with genetic syndromes of extreme insulin resistance.在患有极端胰岛素抵抗遗传综合征患者的培养淋巴细胞中，胰岛素受体降解加速。
J Clin Invest. 1984 Oct;74(4):1366-74. doi: 10.1172/JCI111547.
7
[Insulin-like effects of anti-insulin-receptor antibodies on cultured rat hepatocytes].抗胰岛素受体抗体对培养大鼠肝细胞的胰岛素样作用
Hokkaido Igaku Zasshi. 1985 May;60(3):342-54.
8
Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor.利用抗胰岛素受体的125I标记自身抗体检测和鉴定胰岛素细胞表面受体的直接方法。
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4115-9. doi: 10.1073/pnas.73.11.4115.
9
Insulin receptor binding and degradation in IM-9 cultured human lymphocytes - importance of extracellular degradation.
J Endocrinol Invest. 1980 Jan-Mar;3(1):77-81. doi: 10.1007/BF03348223.
10
Analysis of the insulin receptor by anti-receptor antibodies and flow cytometry.利用抗受体抗体和流式细胞术分析胰岛素受体。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7446-50. doi: 10.1073/pnas.81.23.7446.

引用本文的文献

1
Letter to the Editor From Taylor et al "Type B Insulin Resistance Syndrome: A Rare Cause of Hypoglycemia".泰勒等人致编辑的信《B型胰岛素抵抗综合征：低血糖的罕见病因》
JCEM Case Rep. 2024 Feb 1;2(2):luae001. doi: 10.1210/jcemcr/luae001. eCollection 2024 Feb.
2
Insulin autoimmune syndrome: from diagnosis to clinical management.胰岛素自身免疫综合征：从诊断到临床管理
Ann Transl Med. 2018 Sep;6(17):335. doi: 10.21037/atm.2018.07.32.
3
Antibodies to cell surface proteins redirect intracellular trafficking pathways.抗体靶向细胞表面蛋白可重新定向细胞内运输途径。
Exp Mol Pathol. 2011 Dec;91(3):723-32. doi: 10.1016/j.yexmp.2011.05.011. Epub 2011 Jul 23.
4
Phorbol esters inhibit insulin-induced receptor down-regulation in cultured human lymphocytes: association with diminished insulin receptor autophosphorylation.佛波酯抑制培养的人淋巴细胞中胰岛素诱导的受体下调：与胰岛素受体自身磷酸化减少相关。
Biochem J. 1993 Feb 15;290 ( Pt 1)(Pt 1):151-8. doi: 10.1042/bj2900151.
5
Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor.胰岛素受体酪氨酸激酶结构域突变的显性负效应机制研究。
EMBO J. 1994 Feb 15;13(4):835-42. doi: 10.1002/j.1460-2075.1994.tb06326.x.
6
Analysis of the insulin receptor by anti-receptor antibodies and flow cytometry.利用抗受体抗体和流式细胞术分析胰岛素受体。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7446-50. doi: 10.1073/pnas.81.23.7446.
7
Analysis of insulin receptors on human lymphoblastoid cell lines by flow cytometry.
Diabetologia. 1984 Jul;27 Suppl:118-20. doi: 10.1007/BF00275665.
8
Antibody against the insulin receptor causes disappearance of insulin receptors in 3T3-L1 cells: a possible explanation of antibody-induced insulin resistance.抗胰岛素受体抗体导致3T3-L1细胞中胰岛素受体消失：抗体诱导胰岛素抵抗的一种可能解释。
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2508-11. doi: 10.1073/pnas.81.8.2508.
9
Tyrosine kinase activity of insulin receptors from an insulin-resistant patient with leprechaunism.一名患矮妖精貌综合征的胰岛素抵抗患者胰岛素受体的酪氨酸激酶活性。
Diabetologia. 1987 Aug;30(8):631-7. doi: 10.1007/BF00277320.
10
Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor.将K562细胞暴露于抗受体单克隆抗体OKT9会导致转铁蛋白受体迅速重新分布并加速降解。
J Cell Biol. 1986 Mar;102(3):951-8. doi: 10.1083/jcb.102.3.951.