Blackard W G, Ludeman C H
Horm Metab Res. 1981 Sep;13(9):480-3. doi: 10.1055/s-2007-1019311.
Although anti-insulin receptor antibodies mimic insulin in many of its actions, antireceptor antibodies in serum from a diabetic patient did not share the property of insulin to produce negative cooperativity as defined by the Demeyts experiment. In contrast, an inhibition of insulin dissociation from IM-9 lymphoblastoid cells was observed after exposure to the antireceptor antibody. The capacity of this particular antireceptor antibody to attach to cells whose insulin receptors have been saturated suggests that the antibody may trap insulin by molecular hindrance.
尽管抗胰岛素受体抗体在许多作用方面模拟胰岛素，但糖尿病患者血清中的抗受体抗体并不具备胰岛素在德梅伊茨实验所定义的产生负协同效应的特性。相反，在接触抗受体抗体后，观察到胰岛素从IM-9淋巴母细胞样细胞的解离受到抑制。这种特定抗受体抗体附着于胰岛素受体已饱和的细胞的能力表明，该抗体可能通过分子阻碍作用捕获胰岛素。
