Amano J, Okamura T, Sunamori M, Suzuki A
Jpn J Surg. 1983 Jul;13(4):277-84. doi: 10.1007/BF02469508.
Glucose-insulin-potassium (GIK) solution is widely used as a cardioplegic infusate for myocardial protection during aortic cross-clamping, to obtain rapid diastolic arrest and preservation of energy stores. Nine male patients with aorto-coronary bypass grafting procedure were studied with regard to the metabolic influence of GIK cardioplegia. Hyperglycemia was induced by the infusion of GIK solution for one week after surgery. The serum level of non-esterified fatty acid was high for one week while the triglyceride level was maintained at a high level only in the early post-operative period. Insulin, glucagon and growth hormone which influence carbohydrate and lipid metabolism were also elevated for one week after infusion of GIK solution. We conclude that the derangement of carbohydrate and lipid metabolism which is provoked by the use of GIK cardioplegia normalizes within two weeks after operation.
葡萄糖-胰岛素-钾（GIK）溶液被广泛用作主动脉交叉钳夹期间心肌保护的心脏停搏灌注液，以实现快速舒张期停搏并保存能量储备。对9例行主动脉冠状动脉搭桥术的男性患者进行了GIK心脏停搏代谢影响的研究。术后通过输注GIK溶液诱导高血糖一周。非酯化脂肪酸血清水平在一周内较高，而甘油三酯水平仅在术后早期维持在较高水平。影响碳水化合物和脂质代谢的胰岛素、胰高血糖素和生长激素在输注GIK溶液后一周也升高。我们得出结论，使用GIK心脏停搏引起的碳水化合物和脂质代谢紊乱在术后两周内恢复正常。
