心脏直视手术后钾、葡萄糖和胰岛素的循环效应
Circulatory effects of potassium, glucose and insulin following open-heart surgery.
作者信息
Bradley R D, Branthwaite M A
出版信息
Thorax. 1970 Nov;25(6):716-9. doi: 10.1136/thx.25.6.716.
Abstract
The cardiovascular effects of an acute infusion of potassium, glucose and insulin (PGI) were investigated in 10 subjects following valve replacement surgery. All required circulatory support with isoprenaline and no additional improvement in cardiac function could be demonstrated following PGI. Pressures in both atria rose out of proportion to the volume infused and there were biochemical changes which suggested that haemodilution had occurred. These findings were attributed to the administration of hypertonic dextrose solution and this also resulted in hyperglycaemia, glycosuria and an osmotic diuresis.
摘要
在10例瓣膜置换术后患者中研究了急性输注钾、葡萄糖和胰岛素（PGI）的心血管效应。所有患者均需用异丙肾上腺素进行循环支持，输注PGI后未显示心脏功能有额外改善。两个心房的压力升高与输注量不成比例，并且出现了生化变化，提示发生了血液稀释。这些发现归因于高渗葡萄糖溶液的输注，这还导致了高血糖、糖尿和渗透性利尿。
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