Long W F, Williamson F B
Med Hypotheses. 1983 Jul;11(3):285-308. doi: 10.1016/0306-9877(83)90093-2.
It is postulated that the metabolically variable fine structure of pericellular heparan glycosaminoglycans affects the ability of these molecules to influence cell proliferation-associated proteinase-catalysed reactions occurring at cell surfaces. Evidence suggesting the possibility of a wide repertoire of glycosaminoglycan-mediated positive and negative effects on such reactions is reviewed. It is suggested that clinical administration of compounds related chemically to heparins might usefully modulate cell proliferation-associated proteinase activity.
据推测，细胞周围硫酸乙酰肝素糖胺聚糖的代谢可变精细结构会影响这些分子影响细胞表面发生的与细胞增殖相关的蛋白酶催化反应的能力。本文综述了表明硫酸乙酰肝素糖胺聚糖对这类反应具有广泛的正负调节作用可能性的证据。有人提出，临床应用与肝素化学相关的化合物可能会有效调节与细胞增殖相关的蛋白酶活性。
