Shay J W
Mol Cell Biochem. 1983;57(1):17-26. doi: 10.1007/BF00223521.
A review is presented on 1) the autonomous nature of mammalian cell cytoplasm and 2) the cytoplasmic modification of nuclear gene expression. Topics include a discussion of cytoplasmic suppression of tumorigenicity. It is proposed that alterations in DNA methylation patterns may be a possible mechanism to explain cytoplasmic modification of nuclear gene expression.
1)哺乳动物细胞质的自主性;2)核基因表达的细胞质修饰。主题包括对肿瘤发生的细胞质抑制的讨论。有人提出,DNA甲基化模式的改变可能是解释核基因表达的细胞质修饰的一种可能机制。