口服碳酸钙、氢氧化铝凝胶和双氢速甾醇对肾性酸中毒的影响。

Effect of oral administration of calcium carbonate, aluminum hydroxide gel and dihydrotachysterol on renal acidosis.

作者信息

Ueda H, Ikeda H, Sasaki Y, Shioji R

出版信息

Tohoku J Exp Med. 1978 Jan;124(1):1-11. doi: 10.1620/tjem.124.1.

DOI:10.1620/tjem.124.1

Abstract

The effects of oral administration of calcium carbonate, aluminum hydroxide gel, dihydrotachysterol (DHT) and sodium bicarbonate on metabolic acidosis and plasma calcium and phosphate were studied in 7 patients with chronic renal failure. Single administration of calcium carbonate alleviated the acidosis and increased the urinary bicarbonate excretion. These effects were potentiated when aluminum hydroxide gel was administered in combination with calcium carbonate. The plasma calcium was increased by this combination therapy. The effects of these two agents on acidosis and plasma calcium were further enhanced by the additional administration of DHT. Urinary bicarbonate excretion was less during the treatment with aluminum hydroxide gel and calcium carbonate than with aluminum hydroxide gel and sodium bicarbonate, when the excretions were compared at the similar concentrations of plasma bicarbonate. Aluminum hydroxide gel and DHT are likely to enhance the effect of calcium carbonate, which works as an alkalinizing salt on acidosis, probably through increasing calcium absorption in the intestine. And the three agents suppress the leak of bicarbonate into the urine contributing to the improvement of acidosis.

摘要

对7例慢性肾功能衰竭患者研究了口服碳酸钙、氢氧化铝凝胶、双氢速甾醇（DHT）和碳酸氢钠对代谢性酸中毒以及血浆钙和磷的影响。单次给予碳酸钙可减轻酸中毒并增加尿中碳酸氢盐排泄。当氢氧化铝凝胶与碳酸钙联合给药时，这些作用会增强。联合治疗可使血浆钙升高。额外给予DHT可进一步增强这两种药物对酸中毒和血浆钙的作用。当在相似的血浆碳酸氢盐浓度下比较排泄情况时，氢氧化铝凝胶和碳酸钙治疗期间的尿碳酸氢盐排泄量比氢氧化铝凝胶和碳酸氢钠治疗时少。氢氧化铝凝胶和DHT可能会增强碳酸钙的作用，碳酸钙作为一种碱化盐对酸中毒起作用，可能是通过增加肠道对钙的吸收。并且这三种药物可抑制碳酸氢盐漏入尿液，有助于酸中毒的改善。