环拉马朵——一种新型合成镇痛药。与口服可待因用于术后镇痛的双盲对照研究。

Ciramadol--a new synthetic analgesic. A double-blind comparison with oral codeine for postoperative pain relief.

作者信息

Downing J W, Brock-Utne J G, Holloway A M

出版信息

S Afr Med J. 1983 Dec 10;64(25):978-82.

Abstract

One hundred and eighty patients (American Society of Anesthesiologists rating 1-2) received one of three oral analgesics--ciramadol (Wy. 15705) 20 mg, ciramadol 60 mg or codeine 60 mg--on a double-blind random basis for the relief of pain 24-48 hours after major general surgical, gynaecological or orthopaedic operations. All three analgesics proved equally effective and caused mild sedation only. No patient showed signs of clinical cardiorespiratory depression, and other side-effects were infrequent. Ciramadol may therefore prove a useful clinical alternative to conventional oral analgesics provided its lack of respiratory depressant properties and addiction potential in monkeys can be substantiated in humans.

摘要

180名患者（美国麻醉医师协会分级为1 - 2级）在接受大型普通外科、妇科或骨科手术后24 - 48小时，被随机双盲给予三种口服镇痛药之一——环拉马朵（Wy. 15705）20毫克、环拉马朵60毫克或可待因60毫克——以缓解疼痛。所有三种镇痛药效果相当，仅引起轻度镇静。没有患者出现临床心肺抑制迹象，其他副作用也很少见。因此，如果环拉马朵在猴子身上缺乏呼吸抑制特性和成瘾潜力这一点能在人体中得到证实，那么它可能成为传统口服镇痛药有用的临床替代品。