Fragen R J, Caldwell N J
J Clin Pharmacol. 1982 Oct;22(10):459-65. doi: 10.1002/j.1552-4604.1982.tb02635.x.
Ciramadol, 20, 40, or 60 mg, or a placebo was administered orally, double blind, to patients complaining of moderate (N = 89) or severe (N = 80) postoperative pain to determine the lowest effective dose. The highest dose used for moderate pain, 40 mg, was statistically more effective than placebo as measured by pain intensity differences and pain relief scores. The highest dose used to treat severe pain, 60 mg, was also more effective statistically than placebo and the lower doses of ciramadol at certain points during the 6-hour observation period. Drowsiness was minimal, and side effects were infrequent and mild in intensity. We conclude that 40 mg ciramadol for moderate postoperative pain and 60 mg ciramadol for severe postoperative pain would be the minimal oral doses to compare with standard analgesics in future studies.
将环拉马多20毫克、40毫克或60毫克，或安慰剂进行双盲口服给药，用于治疗主诉中度（N = 89）或重度（N = 80）术后疼痛的患者，以确定最低有效剂量。用于中度疼痛的最高剂量40毫克，通过疼痛强度差异和疼痛缓解评分衡量，在统计学上比安慰剂更有效。用于治疗重度疼痛的最高剂量60毫克，在6小时观察期的某些时间点，在统计学上也比安慰剂和较低剂量的环拉马多更有效。嗜睡情况轻微，副作用发生率低且程度较轻。我们得出结论，在未来研究中，用于中度术后疼痛的环拉马多最低口服剂量为40毫克，用于重度术后疼痛的为60毫克，可与标准镇痛药进行比较。
