Trakhtenberg A Kh, Chissov V I, Kiseleva E S, Barchuk A S, Vagner R I
Vopr Onkol. 1983;29(11):58-67.
The clinical data provided by the members of a CMEA joint study on the problem of Lung Cancer (Work group 3--9.1.1) are analysed. The study undertaken by the researchers of Bulgaria, Hungary, Poland, USSR and Czechoslovakia was concerned with evaluation of the effectiveness of a modality of combined treatment of well--differentiated cancer of the lung. The study group consisted of 286 patients; 231 surgically treated patients were in control. It was found that preoperative intensive concentrated radiation treatment did not interfere with surgical procedures. Nor did it specifically involve any intraoperative complications or change their frequency. However, combined treatment (preoperative irradiation + surgery) was followed by a relatively high mortality and a significant increase in the frequency of postoperative complications, especially purulent ones, such as bronchial fistula and empyema of the pleural cavity. Maximal difference in mortality rates between the groups was observed in cases of stage III cancer. The long-term results were studied in 379 cases (221 patients after combined treatment and 158--after surgery). 76.5 and 77.2, 49.4, and 41.2, and 34.4 and 20.7% of patients survived over one, three and five years, respectively. Better results registered in the study group were largely due to cases of stage III squamous cell carcinoma.
对经互会成员国肺癌问题联合研究（第3工作组——9.1.1）成员提供的临床数据进行了分析。保加利亚、匈牙利、波兰、苏联和捷克斯洛伐克的研究人员开展的这项研究，旨在评估一种肺高分化癌联合治疗方式的有效性。研究组由286名患者组成；231名接受手术治疗的患者作为对照。结果发现，术前强化集中放射治疗并不影响手术操作。它也未特别引发任何术中并发症或改变其发生率。然而，联合治疗（术前放疗+手术）之后，死亡率相对较高，术后并发症发生率显著增加，尤其是脓性并发症，如支气管瘘和胸腔积脓。在III期癌症病例中，两组之间的死亡率差异最大。对379例患者的长期结果进行了研究（221例接受联合治疗，158例接受手术）。分别有76.5%、77.2%、49.4%、41.2%以及34.4%和20.7%的患者存活超过1年、3年和5年。研究组取得的较好结果在很大程度上归因于III期鳞状细胞癌病例。
