Klotz U
Am J Med. 1983 Nov 14;75(5A):133-8. doi: 10.1016/0002-9343(83)90245-0.
Antipyretic analgesics, such as salicylates, acetaminophen, and pyrazolones, are often given concomitantly with a variety of other drugs. Drug interactions that occur at the receptors are known as pharmacodynamic interactions; alterations in absorption (bioavailability), distribution (plasma protein-binding), and elimination (renal excretion, hepatic metabolism) are termed pharmacokinetic interactions. For example, antacids and food both delay the absorption of analgesics. Highly protein-bound drugs (such as phenylbutazone, phenytoin, or warfarin) can compete with the common binding sites of salicylates. Hepatic elimination of salicylates can be influenced by drugs such as beta-blockers and cimetidine. Clinically important interactions involving salicylates, acetaminophen, and other antipyretic analgesics are discussed.
解热镇痛药，如水杨酸盐、对乙酰氨基酚和吡唑酮类，常常与多种其他药物同时使用。在受体处发生的药物相互作用被称为药效学相互作用；吸收（生物利用度）、分布（血浆蛋白结合）和消除（肾脏排泄、肝脏代谢）的改变则被称为药代动力学相互作用。例如，抗酸剂和食物都会延缓镇痛药的吸收。高蛋白结合药物（如保泰松、苯妥英或华法林）可与水杨酸盐的共同结合位点竞争。水杨酸盐的肝脏消除可受到β受体阻滞剂和西咪替丁等药物的影响。本文讨论了涉及水杨酸盐、对乙酰氨基酚和其他解热镇痛药的具有临床重要性的相互作用。
