• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

正常肝功能。理解肝脏疾病的基础。

Normal liver function. A basis for understanding hepatic disease.

作者信息

Corless J K, Middleton H M

出版信息

Arch Intern Med. 1983 Dec;143(12):2291-4. doi: 10.1001/archinte.143.12.2291.

DOI:10.1001/archinte.143.12.2291
PMID:6360063
Abstract

The physiology of the liver involves metabolism, excretion, and body defense. Within the context of metabolism, the liver is the site of a multitude of biochemical reactions essential to the human organism; included are synthesis, degradation, interconversion, storage, and biotransformation. A working knowledge of the relationship between structure and function and of hepatic processes under normal conditions is essential for understanding the derangements observed in clinical diseases affecting the liver. Our overview of hepatic physiology highlights some of these facets of normal hepatic anatomy and function of special relevance to the physician confronting liver dysfunction and its varied clinical consequences.

摘要

肝脏的生理功能涉及代谢、排泄和身体防御。在代谢方面,肝脏是人体不可或缺的众多生化反应发生的场所;这些反应包括合成、降解、相互转化、储存和生物转化。了解正常情况下肝脏的结构与功能之间的关系以及肝脏的生理过程,对于理解影响肝脏的临床疾病中出现的功能紊乱至关重要。我们对肝脏生理学的概述着重介绍了正常肝脏解剖结构和功能的一些方面,这些方面对于面对肝功能障碍及其各种临床后果的医生尤为重要。

相似文献

1
Normal liver function. A basis for understanding hepatic disease.正常肝功能。理解肝脏疾病的基础。
Arch Intern Med. 1983 Dec;143(12):2291-4. doi: 10.1001/archinte.143.12.2291.
2
The liver.肝脏。
Curr Biol. 2017 Nov 6;27(21):R1147-R1151. doi: 10.1016/j.cub.2017.09.019.
3
Hepatic drug metabolism in cystic fibrosis: recent developments and future directions.囊性纤维化中的肝脏药物代谢:最新进展与未来方向。
Ann Pharmacother. 1993 Jan;27(1):74-9. doi: 10.1177/106002809302700117.
4
[Hepatic insufficiency and nutritional problems after major hepatobiliary surgery].[肝胆大手术后的肝功能不全及营养问题]
J Chir (Paris). 1984 Oct;121(10):573-85.
5
The liver. Part 2: Physiology.肝脏。第二部分:生理学。
Nurs Times. 2005;101(49):22-3.
6
Clinical physiology of the liver.肝脏的临床生理学
Br J Anaesth. 1972 Sep;44(9):910-7. doi: 10.1093/bja/44.9.910.
7
Liver: functional interactions within the intact animal.肝脏:完整动物体内的功能相互作用。
Annu Rev Physiol. 1969;31:227-68. doi: 10.1146/annurev.ph.31.030169.001303.
8
Uremia and the liver. III. Uremia and hepatic metabolism of carbohydrates, lipids, and proteins.尿毒症与肝脏。III. 尿毒症与碳水化合物、脂质和蛋白质的肝脏代谢
Nephron. 1981;29(1-2):14-17. doi: 10.1159/000182231.
9
Cell volume in the regulation of hepatic function: a mechanism for metabolic control.
Biochim Biophys Acta. 1991 Dec 12;1071(4):331-50. doi: 10.1016/0304-4157(91)90001-d.
10
Hepatic ontogenesis.
Hepatology. 1985 Nov-Dec;5(6):1213-21. doi: 10.1002/hep.1840050625.

引用本文的文献

1
Placenta nanoparticle treatment in guinea pigs mitigates FGR-associated fetal sex-dependent effects on liver metabolism-related signaling pathways.豚鼠胎盘纳米颗粒治疗可减轻与胎儿生长受限相关的、对肝脏代谢相关信号通路的胎儿性别依赖性影响。
Am J Physiol Endocrinol Metab. 2025 Mar 1;328(3):E395-E409. doi: 10.1152/ajpendo.00440.2024. Epub 2025 Feb 5.
2
Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model.使用大鼠全基因组代谢模型量化剂量依赖性化学暴露引起的肝毒性反应。
Toxicol Sci. 2025 Apr 1;204(2):154-168. doi: 10.1093/toxsci/kfaf005.
3
The relationship between liver enzymes, prehypertension and hypertension in the Azar cohort population.
在阿扎尔队列人群中,肝酶、高血压前期和高血压之间的关系。
BMC Cardiovasc Disord. 2024 Jun 7;24(1):294. doi: 10.1186/s12872-024-03969-x.
4
Sour Tamarind Is More Antihypertensive than the Sweeter One, as Evidenced by In Vivo Biochemical Indexes, Ligand-Protein Interactions, Multitarget Interactions, and Molecular Dynamic Simulation.酸罗望子比甜罗望子具有更强的降压作用,这可以从体内生化指标、配体-蛋白相互作用、多靶相互作用和分子动力学模拟得到证明。
Nutrients. 2023 Jul 31;15(15):3402. doi: 10.3390/nu15153402.
5
Liver Organoid Potential Application for Hepatitis E Virus Infection.类肝器官在戊型肝炎病毒感染中的潜在应用。
Adv Exp Med Biol. 2023;1417:133-139. doi: 10.1007/978-981-99-1304-6_9.
6
Association between raised blood pressure and elevated serum liver enzymes among active-duty Royal Thai Army personnel in Thailand.泰国现役皇家泰军人员中血压升高与血清肝酶升高之间的关联。
BMC Cardiovasc Disord. 2023 Mar 21;23(1):143. doi: 10.1186/s12872-023-03181-3.
7
Targeted delivery of oligonucleotides using multivalent protein-carbohydrate interactions.利用多价蛋白-碳水化合物相互作用靶向递送寡核苷酸。
Chem Soc Rev. 2023 Feb 20;52(4):1273-1287. doi: 10.1039/d2cs00788f.
8
The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease.磷酸酶PTEN和TCPTP的氧化失活在脂肪肝疾病中的作用
Antioxidants (Basel). 2023 Jan 3;12(1):120. doi: 10.3390/antiox12010120.
9
Comprehensive Approach to Assessment of Liver Viability During Normothermic Machine Perfusion.常温机器灌注期间肝脏活力评估的综合方法
J Clin Transl Hepatol. 2023 Apr 28;11(2):466-479. doi: 10.14218/JCTH.2022.00130. Epub 2022 Sep 13.
10
A Review of Stem Cell Technology Targeting Hepatocyte Growth as an Alternative to Organ Transplantation.干细胞技术在肝细胞生长中的应用综述:作为器官移植的替代方法。
Methods Mol Biol. 2023;2575:181-193. doi: 10.1007/978-1-0716-2716-7_9.