Strukov A I
Arkh Patol. 1983;45(9):73-6.
On the basis of the literature analysis and own observations the author concludes that the process of inflammation involves all the components of the microcirculatory bed and the endothelial lining: arterioles, blood precapillaries, capillaries, postcapillaries, venules, lymph capillaries, systems of the interstitial tissue channels as well as the connective tissue rich in hyaluronic acid and proteoglycans. The emergence of all cardinal signs of inflammation is associated with damage of different components of the microcirculatory bed. Intensive peroxidation of lipids ("oxidative stress") was observed in the focus of inflammation. Microcirculatory disorders in the inflammation focus are always synchronously accompanied by activation of blood plasma protein systems: coagulation, anticoagulation, kinin, complementary.
基于文献分析和自身观察,作者得出结论:炎症过程涉及微循环床和内皮衬里的所有组成部分,包括小动脉、血液前毛细血管、毛细血管、后毛细血管、小静脉、淋巴毛细血管、间质组织通道系统以及富含透明质酸和蛋白聚糖的结缔组织。炎症所有主要体征的出现都与微循环床不同组成部分的损伤有关。在炎症病灶处观察到脂质的强烈过氧化(“氧化应激”)。炎症病灶处的微循环障碍总是同时伴有血浆蛋白系统的激活,包括凝血、抗凝、激肽、补体系统。