Khoury G A, Farrington K, Varghese Z, Persaud J W, Irving J D, Fernando O N, Moorhead J F, Sweny P
Clin Nephrol. 1983 Nov;20(5):225-30.
Forty-four hypertensive transplant patients were investigated by digital vascular imaging of the graft and simultaneous selective venous sampling for plasma renin activity to attempt to identify those patients whose hypertension may be amenable to surgical treatment. Localization of renin hypersecretion was possible in 12 patients. In ten of these, hypersecretion originated from the native kidney and in two from the graft. Localization was possible in a significantly higher proportion of patients with severe hypertension (8 of 17), and all of these had native kidney hypersecretion. Bilateral nephrectomy may be indicated in these patients. No cases of functionally significant renal artery stenosis were identified. The other major types of abnormal vascular pattern found on digital vascular imaging, diffuse intra-renal arterial attenuation and lower pole hypoperfusion may be secondary to hypertension. This combined technique may be useful in the evaluation of post-transplant hypertension, especially when hypertension is severe.
对44例高血压移植患者进行了移植物数字血管成像检查，并同时进行选择性静脉采血检测血浆肾素活性，以试图确定那些高血压可能适合手术治疗的患者。12例患者能够确定肾素分泌过多的部位。其中10例，分泌过多源于自身肾脏，2例源于移植物。重度高血压患者中能够确定分泌过多部位的比例显著更高（17例中有8例），且所有这些患者的自身肾脏均分泌过多。这些患者可能需要行双侧肾切除术。未发现有功能意义的肾动脉狭窄病例。数字血管成像发现的其他主要异常血管模式，即肾内动脉弥漫性变细和下极灌注不足，可能是高血压的继发表现。这种联合技术在评估移植后高血压时可能有用，尤其是在高血压较为严重的情况下。
