某些二（硝基噻吩基）和二（乙酰氨基噻吩基）砜的合成及生物活性
Synthesis and biological activity of some di(nitrothienyl)- and di(acetylaminothienyl)sulfones.
作者信息
Ronsisvalle G, Vittorio F, Pappalardo M S
出版信息
Farmaco Sci. 1983 Nov;38(11):877-83.
PMID:6360709
Abstract
Some new di(nitrothienyl)- and di(acetylaminothienyl)sulfones were synthesized. Compounds (I)-(VI) were active against several Gram-positive bacteria, in vitro. Di(5-acetylamino-2-thienyl)sulfone (VII) showed a mild antimalarial activity against a drug-sensitive strain of P. berghei in mice.
摘要
合成了一些新的二（硝基噻吩基）和二（乙酰氨基噻吩基）砜。化合物（I）-（VI）在体外对几种革兰氏阳性菌具有活性。二（5-乙酰氨基-2-噻吩基）砜（VII）对小鼠体内伯氏疟原虫的药物敏感株显示出轻微的抗疟活性。
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