Roloff M V, D'Addario A P, Buffum E J
Undersea Biomed Res. 1978 Mar;5(1):15-23.
The sublethal effects of carbon monoxide (CO) in hyperbaric environments have not been adequately characterized. A physiologically sensitive indicator of sublethal effects of a contaminant is the pulmonary alveolar macrophage (PAM). The guinea pig PAM and its reaction to various CO concentrations at 8 atmospheres absolute (ATA) and the surface-equivalent concentrations at 1 ATA were studied in this experiment. In the absence of CO, PAM counts and viabilites from guinea pigs exposed to a helium-oxygen environment at either 1 or 8 ATA were not significantly different from one another. Mean PAM viability for guinea pigs exposed to CO concentrations at 2250--4200 mg/m3 at 8 ATA was 68.4 +/- 7.3% and was not significantly different from the 1-ATA viability value of 72.0 +/- 4.5% for the 1600--4200 mg/m3 CO range. The data show that at 1 to 8 ATA and CO concentrations of 1600--4200 mg/m3, the decrease in PAM viability was accompanied by dramatic five- to sixfold increases in PAM counts.
高压环境中一氧化碳（CO）的亚致死效应尚未得到充分描述。污染物亚致死效应的一个生理敏感指标是肺泡巨噬细胞（PAM）。本实验研究了豚鼠PAM及其在8个绝对大气压（ATA）下对各种CO浓度以及1个ATA下表面等效浓度的反应。在没有CO的情况下，暴露于1或8个ATA的氦氧环境中的豚鼠的PAM计数和活力彼此之间没有显著差异。暴露于8个ATA下2250--4200 mg/m3 CO浓度的豚鼠的平均PAM活力为68.4 +/- 7.3%，与1600--4200 mg/m3 CO范围内1个ATA活力值72.0 +/- 4.5%没有显著差异。数据表明，在1至8个ATA以及1600--4200 mg/m3的CO浓度下，PAM活力的降低伴随着PAM计数急剧增加五到六倍。
