Comparison between fenoprofen and ibuprofen in the treatment of soft-tissue rheumatism.

Fenoprofen calcium 600 mg, four times daily, and ibuprofen 400 mg, four times daily, were compared in a double-blind crossover study involving the treatment of soft-tissue rheumatism in fifty patients. After 7 days there was no significant difference between the efficacy of the two drugs with respect to 'pain at rest', 'pain on movement', 'tenderness' or 'sleep disturbance' but fenoprofen was significantly better when considering 'limitation of movement' and 'The physician's assessment of the severity of the condition'. Combining data from Weeks 1 and 2 of treatment, 14 days fenoprofen treatment brought about significant improvements in all of the above parameters. Ibuprofen did not significantly improve 'pain at rest' but did improve the other parameters.