Nolan R J, Dodd D E, Faiman M D
Undersea Biomed Res. 1978 Mar;5(1):87-93.
Studies were carried out to determine the effect of high oxygen pressure (OHP) on brain and blood glucose. OHP increased cerebral glucose in mice killed at various stages of oxygen toxicity. This included times which corresponded to 75% and 100% of the CT50, the hyperactive state, and at seizure onset. Blood glucose also was increased but only when mice were exposed to oxygen for times which produced stress-related responses. These were at 100% of the CT50,during hyperactivity, and at the onset of seizures. The increase in cerebral glucose was due to the increased oxygen pressure and not to the pressure per se. Adrenalectomy blocked the oxygen-induced increase in blood glucose but not in cerebral glucose. Disulfiram, an effective oxygen protectant, markedly increased both brain and blood glucose.
开展了多项研究以确定高氧压（OHP）对大脑和血糖的影响。在氧中毒不同阶段处死的小鼠中，OHP增加了脑葡萄糖含量。这包括对应于CT50的75%和100%的时间、多动状态以及癫痫发作开始时。血糖也升高了，但仅在小鼠暴露于氧气的时间产生与应激相关反应时才会升高。这些时间是在CT50的100%、多动期间以及癫痫发作开始时。脑葡萄糖的增加是由于氧压升高而非压力本身。肾上腺切除术可阻断氧诱导的血糖升高，但不能阻断脑葡萄糖升高。双硫仑是一种有效的氧保护剂，可显著增加脑和血糖。
