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[药物对机械性诱发瘙痒及皮肤相应的红斑和风团的作用。临床实验研究]

[Drug modification of mechanically evoked itching and the concomitant equivalents, erythema and wheals of the skin. Clinico-experimental studies].

作者信息

Haas P J

出版信息

Fortschr Med. 1983 Nov 10;101(42):1939-43.

PMID:6360832
Abstract

In 20 volunteers with normal skin, itching and concomitant erythemas and wheals were produced by mechanical stimulation with a magnetic oscillation system. In a placebo-controlled, randomized double-blind study with twice cross-over, a calcium-vitamin-D-combination as single dose ampoules for peroral application was tested. A significant decrease (p less than 0,001) of the areas of erythema and wheal and itching in treated persons, compared with non-treated and placebo-treated volunteers serving for controls, is showing the antiallergic effectiveness of the tested preparation.

摘要

在20名皮肤正常的志愿者中,用磁振荡系统进行机械刺激可引发瘙痒以及伴随的红斑和风团。在一项安慰剂对照、随机双盲、两次交叉的研究中,对一种口服单剂量安瓿装的钙 - 维生素D组合制剂进行了测试。与未治疗以及作为对照的接受安慰剂治疗的志愿者相比,接受治疗者的红斑、风团面积以及瘙痒程度显著降低(p < 0.001),这表明了受试制剂的抗过敏效果。

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