恶性和良性淋巴滤泡中心核大小的研究。
Study of nuclear sizes in the centres of malignant and benign lymphoid follicles.
作者信息
Crocker J, Jones E L, Curran R C
出版信息
J Clin Pathol. 1983 Dec;36(12):1332-4. doi: 10.1136/jcp.36.12.1332.
The sizes of follicle centre cells in 15 specimens of follicular (centroblastic-centrocytic) non-Hodgkin's lymphoma and 15 specimens of reactive follicular hyperplasia have been measured. The findings differ from previous studies, where nuclei of cells from follicle centres and interfollicular areas were measured and revealed no significant difference between follicular lymphoma and reactive follicular hyperplasia. In the current study, by measuring only follicle centre cell nuclei, it has been found that, in reactive follicular hyperplasia, the mean nuclear maximum diameter (Dmax) and area are significantly greater than in centroblastic-centrocytic follicular lymphoma. In addition, the standard deviation of these data is greater for reactive follicular hyperplasia than follicular lymphoma, implying greater "scatter" or heterogeneity of the nuclear sizes in the follicle centre cells of the former than the latter. Thus, the size of these cells appears to be of value as an histological discriminator between these benign and malignant conditions.
已对15例滤泡性（中心母细胞-中心细胞型）非霍奇金淋巴瘤标本和15例反应性滤泡增生标本中的滤泡中心细胞大小进行了测量。这些发现与先前的研究不同，先前的研究测量了滤泡中心和滤泡间区域细胞的细胞核，结果显示滤泡性淋巴瘤和反应性滤泡增生之间无显著差异。在当前研究中，仅通过测量滤泡中心细胞核发现，在反应性滤泡增生中，平均核最大直径（Dmax）和面积显著大于中心母细胞-中心细胞型滤泡性淋巴瘤。此外，反应性滤泡增生这些数据的标准差大于滤泡性淋巴瘤，这意味着前者滤泡中心细胞的核大小比后者具有更大的“离散度”或异质性。因此，这些细胞的大小似乎可作为区分这些良性和恶性病变的组织学鉴别指标。
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