Wideröe T E, Smeby L C, Myking O L, Wessel-Aas T
Proc Eur Dial Transplant Assoc. 1983;20:195-200.
The insulin and C-peptide kinetics due to glucose (50 g), given intraperitoneally or enterally has been compared in five non-diabetic patients on continuous ambulatory peritoneal dialysis (CAPD). The fasting C-peptide concentrations were three to ten times the normal values whereas the fasting plasma insulin concentrations were within normal limits. After intraperitoneal glucose administration a more marked hyperglycaemia (p less than 0.05) and a more long lasting hyperinsulinaemia (p less than 0.05) was found than after the enteral glucose load. The relative change in plasma C-peptide was slower and less pronounced in both experiments. C-peptide concentration in plasma did not differ significantly between the two experiments. Estimated total body clearance (Kt) for insulin was higher than for C-peptide (p less than 0.01), but dialysis clearance (Kd) for C-peptide was higher than for insulin in both experiments (p less than 0.01).
在5名接受持续非卧床腹膜透析（CAPD）的非糖尿病患者中，比较了经腹腔或经肠道给予50克葡萄糖后胰岛素和C肽的动力学。空腹C肽浓度是正常值的三到十倍，而空腹血浆胰岛素浓度在正常范围内。腹腔内给予葡萄糖后，与经肠道给予葡萄糖负荷相比，发现有更明显的高血糖（p<0.05）和更持久的高胰岛素血症（p<0.05）。在两个实验中，血浆C肽的相对变化都较慢且不太明显。两个实验中血浆C肽浓度无显著差异。胰岛素的估计全身清除率（Kt）高于C肽（p<0.01），但在两个实验中，C肽的透析清除率（Kd）均高于胰岛素（p<0.01）。
