Fuchs C, Armstrong V W, Dorn D, Ebert R, Scheler F
Z Urol Nephrol. 1982 Jun;75(6):415-27.
During the past few years continuous ambulatory peritoneal dialysis (CAPD) has become well established in the home treatment of uremia. CAPD, however, may induce certain biochemical abnormalities. Using glucose as an osmotic agent of the dialysate the peritoneal glucose load may vary between 75 and 200 g per day, depending upon how often high osmotic dialysate is needed. If the latter is restricted to one bag per day a long-term disturbance of the glucoregulatory hormones insulin, GIP an glucagon seem to be inprobable. Investigations into glucose tolerance after 23 til 34 months of CAPD treatment in 4 patients did not indicate any exhaustion of the pancreatic beta-cells. Long-term evaluation into the metabolism of lipoproteins, total plasma proteins, aminoacids and trace elements did not show significant abnormalities induced by CAPD itself. Biochemical alterations observed are more or less related to the uremic state of the patients.
在过去几年中，持续性非卧床腹膜透析（CAPD）已在尿毒症的家庭治疗中得到广泛应用。然而，CAPD可能会引发某些生化异常。使用葡萄糖作为透析液的渗透剂时，根据高渗透析液的使用频率，每日腹膜葡萄糖负荷量可能在75至200克之间变化。如果高渗透析液限制为每天一袋，那么似乎不太可能长期干扰胰岛素、胃抑肽和胰高血糖素等葡萄糖调节激素。对4例患者进行23至34个月CAPD治疗后的葡萄糖耐量研究并未表明胰腺β细胞有任何衰竭迹象。对脂蛋白、总血浆蛋白、氨基酸和微量元素代谢的长期评估并未显示CAPD本身会引起显著异常。观察到的生化改变或多或少与患者的尿毒症状态有关。
