Opie L H
Department of Medicine, University of Cape Town, Medical School, Observatory, Republic of South Africa.
Cardiovasc Drugs Ther. 1988 Jul;2(2):191-203. doi: 10.1007/BF00051234.
Second-generation agents include new dihydropyridines, such as amlodipine, felodipine, isradipine, nicardipine, nimodipine, nisoldipine, and nitrendipine. Verapamil-like agents include tiapamil, gallopamil, and anipamil. Among the diphenylalkylamines, bepridil is of special interest. New preparations of existing agents include slow-release formulations of nifedipine, verapamil, and diltiazem. From all these agents will be selected those that are longer-acting and provide higher vascular selectivity.
第二代药物包括新的二氢吡啶类药物，如氨氯地平、非洛地平、伊拉地平、尼卡地平、尼莫地平、尼索地平以及硝苯地平。维拉帕米类药物包括替帕米、加洛帕米和阿尼帕米。在二苯烷基胺类药物中，苄普地尔尤其值得关注。现有药物的新制剂包括硝苯地平、维拉帕米和地尔硫䓬的缓释制剂。将从所有这些药物中选择作用时间更长且具有更高血管选择性的药物。
