[重铬酸钾对大肠杆菌细胞的诱变及DNA损伤作用]
[Mutagenic and DNA-damaging effect of potassium bichromate in Escherichia coli cells].
作者信息
Kalinina L M, Minseitova S R
出版信息
Genetika. 1983 Dec;19(12):1941-7.
PMID:6363206
Abstract
Mutagenic effects and DNA degradation in Escherichia coli cells treated with potassium bichromate were studied in this work. It is estimated that events taking place in cells treated with the mutagen are controlled by recB recC and sbcB gene products. The method for sedimentation analysis has revealed DNA degradation. The use of the impulse label of 3H-thymidine made it possible to detect DNA breaks in the daughter strands. This effect of potassium bichromate on DNA degradation is, possibly, connected with mutagenic repair.
摘要
本研究探讨了重铬酸钾处理的大肠杆菌细胞中的诱变效应和DNA降解。据估计，用诱变剂处理的细胞中发生的事件受recB、recC和sbcB基因产物的控制。沉降分析方法揭示了DNA降解。使用3H-胸腺嘧啶脉冲标记能够检测子链中的DNA断裂。重铬酸钾对DNA降解的这种作用可能与诱变修复有关。
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