A case of membranous proliferative glomerulonephritis type III (Burkholder) with the deposition of both HBeAg and HBsAg.

A case of HB virus associated MPGN type III was described for the first time in a 10 year old Japanese girl. She was followed for a period of 7 years with serial serological work-up and renal biopsy. When she was found seropositive for HBe antigen was stained predominantly in capillary walls, but HBs antigen was also detected in capillary walls and mesangium. The results suggest that both HBe- and HBs antigen antibody immune complexes may play a significant role in the development of HB virus associated nephropathy; HBe antigen for MGN and HBe- and HBs antigens for MPGN type III. Although HB virus associated nephropathy is believed to be a rather benign disorder, the present case warrants a close follow-up because of chronicity of massive proteinuria and renal pathology.