保钾利尿剂：老年男性中与地高辛的相互作用。

Potassium-sparing diuretics: interaction with digoxin in elderly men.

作者信息

Finnegan T P, Spence J D, Cape R D

出版信息

J Am Geriatr Soc. 1984 Feb;32(2):129-31. doi: 10.1111/j.1532-5415.1984.tb05853.x.

DOI:10.1111/j.1532-5415.1984.tb05853.x

Abstract

The effects of two potassium-sparing diuretic combination drugs, triamterene-hydrochlorothiazide and spironolactone-hydrochlorothiazide, were compared with those of two kaliuretic diuretics, hydrochlorothiazide and furosemide, in order to ascertain the effects of those diuretics on concentrations of serum digoxin, serum potassium, and erythrocyte potassium, and to determine whether any of these diuretics should be preferred for patients taking digoxin. It was concluded that in patients for whom potassium depletion may lead to digoxin toxicity, a potassium-sparing diuretic may safely be used in order to reduce potassium excretion and thereby reduce the risk of arrhythmias.

摘要

比较了两种保钾利尿联合用药（氨苯蝶啶-氢氯噻嗪和螺内酯-氢氯噻嗪）与两种排钾利尿剂（氢氯噻嗪和呋塞米）的效果，以确定这些利尿剂对血清地高辛浓度、血清钾和红细胞钾浓度的影响，并确定服用地高辛的患者是否应优先选用其中任何一种利尿剂。得出的结论是，对于钾缺乏可能导致地高辛中毒的患者，可以安全使用保钾利尿剂以减少钾排泄，从而降低心律失常的风险。