服用固定复方利尿剂的老年患者的血浆电解质
Plasma electrolytes in elderly patients taking fixed combination diuretics.
作者信息
Bayer A J, Farag R, Browne S, Pathy M S
出版信息
Postgrad Med J. 1986 Mar;62(725):159-62. doi: 10.1136/pgmj.62.725.159.
Abstract
Plasma potassium and sodium concentrations were measured in a group of elderly patients taking maintenance thiazide diuretic therapy alone, with a potassium supplement or in combination with a potassium sparing diuretic. Fixed dose combinations of a thiazide and potassium sparing diuretic did not significantly reduce the prevalence of hypokalaemia and the combination of amiloride-hydrochlorothiazide was associated with a disproportionate number of cases of hyponatraemia. The desirability of the current widespread use of fixed dose combination diuretics over less expensive single agents is questioned.
摘要
对一组单独接受噻嗪类利尿剂维持治疗、同时服用钾补充剂或与保钾利尿剂联合使用的老年患者进行了血浆钾和钠浓度的测量。噻嗪类利尿剂与保钾利尿剂的固定剂量组合并未显著降低低钾血症的患病率，而阿米洛利 - 氢氯噻嗪组合与不成比例数量的低钠血症病例相关。有人质疑当前广泛使用固定剂量组合利尿剂而非成本较低的单一药物是否合理。
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