Al-Damluji S, Thompson P J, Citron K M, Turner-Warwick M
Thorax. 1983 Dec;38(12):914-8. doi: 10.1136/thx.38.12.914.
To determine whether the endogenous opioid peptides play a part in the pathogenesis of asthmatic morning dipping, six patients with chronic asthma with a reproducible peak flow pattern of morning dipping were investigated in a double blind, randomised, crossover study of naloxone versus placebo. Naloxone was given as a loading dose of 8 mg followed by a continuous infusion of 5.6 mg/h from midnight until 10 am on two consecutive nights. Naloxone had no significant effect on PEFR, FEV1, or FVC at 6 am. There was, however, an improvement over placebo values in all these indices between the hours of 8 am and 8 pm on the day after the first naloxone infusion in all six patients. This effect was not observed after the second naloxone infusion.
为了确定内源性阿片肽是否在哮喘晨峰现象的发病机制中起作用，我们对6例具有可重复的晨峰流量模式的慢性哮喘患者进行了一项双盲、随机、交叉研究，比较纳洛酮与安慰剂的效果。纳洛酮的给药方式为：先给予8mg的负荷剂量，然后从午夜至上午10点连续两晚以5.6mg/h的速度持续输注。上午6点时，纳洛酮对呼气峰流速（PEFR）、第一秒用力呼气容积（FEV1）或用力肺活量（FVC）均无显著影响。然而，在6例患者中，首次输注纳洛酮后的第二天上午8点至晚上8点之间，所有这些指标相对于安慰剂组的值均有改善。第二次输注纳洛酮后未观察到这种效果。
