Connolly C K
Respiration. 1981;42(4):258-62. doi: 10.1159/000194440.
Atopic subjects with asthma are frequently hypersensitive to house dust mite (Dermatophagiodes pyteronyssinus). Exaggerated nocturnal or early morning wheezing might occur in these patients, because of exposure to the allergen during the night, particularly in view of the biphasic response that it produces in airway resistance. This might be of diagnostic value in determining the relevance of house dust mite to the asthma of a particular subject. This hypothesis was tested in 100 patients with diurnal variation in airway obstruction, 78 of whom were predominantly asthmatic. Hypersensitivity to house dust mite was measured by a simple prick test. Morning dipping was seen in patients without hypersensitivity to house dust mite. There was no significant quantitative relationship between morning dip and hypersensitivity. There was a significant relationship between morning dip and severity of wheeze. This study confirms the view that morning dipping is a reflection of the severity of asthma, rather than a feature of any particular type.
患有哮喘的特应性个体通常对屋尘螨（粉尘螨）高度敏感。这些患者可能会出现夜间或清晨加剧的喘息，因为夜间接触了过敏原，特别是考虑到其在气道阻力中产生的双相反应。这对于确定屋尘螨与特定个体哮喘的相关性可能具有诊断价值。在100例气道阻塞存在日变化的患者中对这一假设进行了测试，其中78例以哮喘为主。通过简单的点刺试验测量对屋尘螨的超敏反应。在对屋尘螨无超敏反应的患者中观察到清晨下降。清晨下降与超敏反应之间没有显著的定量关系。清晨下降与喘息严重程度之间存在显著关系。这项研究证实了这样一种观点，即清晨下降反映的是哮喘的严重程度，而非任何特定类型的特征。
