Grodzińska L, Basista M, Kedzior A, Korbut R, Kostka-Trabka E, Gryglewski R
Thromb Haemost. 1983 Dec 30;50(4):797-9.
Twenty-one patients with arteriosclerosis obliterans of lower extremities were treated with beta-pyridylcarbinol (Ronicol) for five weeks. The long-term therapy with beta-pyridylcarbinol did not influence platelet aggregability. Activation of the fibrinolytic system was observed. This fibrinolytic effect of Ronicol was abolished in patients treated with aspirin. In most cases a slight clinical improvement was seen, manifested by elongation of pain-free walking distance and increased blood flow in affected limbs. It is concluded that the therapeutic effect of Ronicol in humans may be partly mediated by the release of endogenous prostacyclin.
21例下肢动脉硬化闭塞症患者接受了β-吡啶甲醇（苄醇烟酸酯）治疗，为期五周。β-吡啶甲醇的长期治疗对血小板聚集性没有影响。观察到纤维蛋白溶解系统被激活。在用阿司匹林治疗的患者中，苄醇烟酸酯的这种纤溶作用被消除。在大多数情况下，可看到轻微的临床改善，表现为无痛行走距离延长和患肢血流量增加。得出的结论是，苄醇烟酸酯对人体的治疗作用可能部分是由内源性前列环素的释放介导的。
