Dembińska-Kieć A, Korbut R, Bierón K, Kostka-Trabka E, Gryglewski R J
Pharmacol Res Commun. 1983 Apr;15(4):377-85. doi: 10.1016/s0031-6989(83)80047-2.
Beta-pyridylcarbinol (Ronicol) when injected (1,2-1,4 mg/kg i.v.) into four patients with arteriosclerosis obliterans caused a release of an unstable disaggregatory substance into arterial blood of those patients. This release was not observed in other two patients who had been pretreated with aspirin (1,8 g p.o.daily). It is postulated that some of pharmacological properties of nicotinic acid derivatives are mediated through the release of endogenous PGI2-like substance.
β-吡啶甲醇（Ronicol）以1.2 - 1.4毫克/千克静脉注射给4例闭塞性动脉硬化患者时，这些患者的动脉血中会释放出一种不稳定的解聚物质。在另外两名每天口服1.8克阿司匹林进行预处理的患者中未观察到这种释放。据推测，烟酸衍生物的某些药理特性是通过内源性前列环素样物质的释放介导的。
