Connor C G, Vassalluzzo P, Sheffield J B, Brownstein B L
Tissue Cell. 1983;15(6):983-92. doi: 10.1016/0040-8166(83)90063-0.
The antipsychotic drug trifluoperazine (TFP) causes a reversible rounding of cells of the rat liver epithelial cell line, WIRL. We have investigated the cytoplasmic organization of these cells after TFP treatment using SEM, TEM and immunofluorescence and have observed significant differences between the control and treated cells. Mitochondria are converted to the condensed configuration with distended cristae and the endoplasmic reticulum becomes tubular with distended cisternae. Intermediate filaments, visualized with a monoclonal antibody, are aggregated to a cap on the nucleus in an arrangement different from that induced by colcemid.
抗精神病药物三氟拉嗪（TFP）会导致大鼠肝上皮细胞系WIRL的细胞发生可逆性变圆。我们使用扫描电子显微镜（SEM）、透射电子显微镜（TEM）和免疫荧光技术研究了TFP处理后这些细胞的细胞质结构，并且观察到对照细胞和处理后细胞之间存在显著差异。线粒体转变为嵴扩张的致密形态，内质网变成潴泡扩张的管状结构。用单克隆抗体显示的中间丝聚集在细胞核上形成一个帽状结构，其排列方式与秋水仙酰胺诱导的不同。
