Pereira R de D, Hermes-Lima M
Department of Biochemistry, Universidade Estadual Paulista (UNESP), Araraquara, São Paulo, Brazil.
Eur J Drug Metab Pharmacokinet. 1996 Oct-Dec;21(4):281-4. doi: 10.1007/BF03189728.
Trifluoperazine (TFP) (35 microM) prevents mitochondrial transmembrane potential (delta psi) collapse and swelling induced by 10 microM Ca2+ plus oxyradicals generated from delta-aminolevulinic acid autoxidation. In contrast with EGTA, TFP cannot restore the totally collapsed delta psi. So, TFP might not remove Ca2+ from its 'harmful site', but could impair the ROS-driven cross-linking between membrane-SH proteins. Our data are correlated with the protective uses of TFP against oxidative processes promoted by oxyradicals plus Ca2+.
三氟拉嗪（TFP）（35微摩尔）可防止由10微摩尔钙离子加δ-氨基乙酰丙酸自氧化产生的氧自由基所诱导的线粒体跨膜电位（δψ）崩溃和肿胀。与乙二醇双四乙酸（EGTA）不同，TFP无法恢复完全崩溃的δψ。因此，TFP可能无法将钙离子从其“有害位点”移除，但可能会损害活性氧驱动的膜-巯基蛋白之间的交联。我们的数据与TFP对氧自由基加钙离子所促进的氧化过程的保护作用相关。
