Royce S M, Holmes R P, Takagi T, Kummerow F A
Am J Clin Nutr. 1984 Feb;39(2):215-22. doi: 10.1093/ajcn/39.2.215.
Weanling swine were fed for 6 months high fat diets containing as fat source, a high oleic acid safflower oil, lard, or a partially hydrogenated soybean oil blended with soybean oil. The extent of atherosclerosis in left coronary arteries and the ability of vascular components to synthesize eicosanoids important for blood clotting were determined. There was no significant difference (p greater than 0.05) in the extent of atherosclerosis or the synthesis of thromboxane A2. Significant effects were observed on serum cholesterol, which was elevated in the lard fed group, serum triacylglycerol, which was highest in the safflower oil group, and prostacyclin synthesis, which was depressed in both the lard and hydrogenated soybean oil diets compared to the safflower oil diet. No unique effect on the development of heart disease appears to be attributable to hydrogenated fats. The hydrogenated fat was similar to lard in decreasing prostacyclin synthesis, suggesting that the saturation of dietary fatty acids may be a contributory factor in the development of heart disease, through its effect on thrombotic processes.
将断奶仔猪喂食含高油酸红花油、猪油或部分氢化大豆油与大豆油混合油作为脂肪来源的高脂日粮6个月。测定左冠状动脉粥样硬化程度以及血管成分合成对血液凝固重要的类二十烷酸的能力。在动脉粥样硬化程度或血栓素A2合成方面没有显著差异（p大于0.05）。观察到对血清胆固醇有显著影响，猪油喂养组血清胆固醇升高；对血清三酰甘油有显著影响，红花油组血清三酰甘油最高；对前列环素合成有显著影响，与红花油日粮相比，猪油和氢化大豆油日粮中的前列环素合成均受到抑制。氢化脂肪似乎对心脏病的发展没有独特影响。氢化脂肪在降低前列环素合成方面与猪油相似，这表明膳食脂肪酸的饱和度可能通过其对血栓形成过程的影响，成为心脏病发展的一个促成因素。
