Toda T, Toda Y, Yamamoto V K, Kummerow F A
J Nutr Sci Vitaminol (Tokyo). 1985 Apr;31(2):233-41. doi: 10.3177/jnsv.31.233.
Three groups of two-month-old swine were fed on basal diets supplemented with either oleic acid-rich safflower oil, lard or hydrogenated soybean oil in order to monitor the atherogenecity of various dietary fatty acids. The level of plasma triglyceride was highest in the safflower oil group and the level of plasma cholesterol was highest in the lard group. The degree of intimal thickening of the coronary arteries was most severe in the safflower oil group and lease severe in the hydrogenated fat group. Both the lard- and safflower oil-supplemented groups displayed lipid-rich coronary arterial lesions. The thickened intima of these two groups contained numerous activated smooth muscle cells, degenerated cells with or without stainable lipid and abundant cell debris. Cellular changes were less conspicuous in the coronary arteries from the hydrogenated fat group than in those from the other two groups.
将三组两个月大的猪分别喂食添加了富含油酸的红花油、猪油或氢化大豆油的基础日粮，以监测各种膳食脂肪酸的致动脉粥样化性。红花油组的血浆甘油三酯水平最高，猪油组的血浆胆固醇水平最高。冠状动脉内膜增厚程度在红花油组最为严重，在氢化脂肪组最轻。添加猪油和红花油的两组均出现富含脂质的冠状动脉病变。这两组增厚的内膜含有大量活化的平滑肌细胞、有或无可染色脂质的退化细胞以及大量细胞碎片。氢化脂肪组冠状动脉的细胞变化比其他两组冠状动脉的细胞变化不那么明显。
